Construct monitoring boundariesFunctions to compute rejection boundaries |
|
---|---|
Get Pocock or OBF-style boundaries at the design stage |
|
Derive boundaries with alpha-spending. |
|
Get adjusted p-valuesFunctions to compute adjusted p-values |
|
Get a stage-wise p-value after the trial is complete. |
|
Alpha-spendingAlpha-spending functions |
|
Pocock approximation, alpha spending function |
|
O'Brien-Fleming approximation, alpha spending function |